The present work is concerned with the formulation of oral dispersible tablets of escitalopram by using natural and synthetic superdisintegrants. Escitalopram is an anti-psychotic drug comes under BCS-II which has low solubility and high permeability. The solubility of the dug can be increased by complexation. Inclusion complexes of escitalopram with β- cyclodextrin have been prepared in the ratio of 1:1, 1:3 and 1:5 and the inclusion complexes containing 1:3 has shown 87% increased aqueous solubility when compared with pure drug. Preformulation studies like solubility, melting point, drug- carrier interaction studies were conducted. FTIR studies reveals no interaction between drug and carrier. In this study, natural super disintegrating agent used was dehydrated banana powder and synthetic one is crospovidone. Six formulations were prepared using different concentrations of superdisintegrants like dehydrated banana powder and cross povidone by using direct compression method. All the formulations were evaluated for precompression tests like bulk density, tapped density, hausners ratio and Carr’s index and all the parameters were found to be within the pharmacopoeial limits. Post compression parameters like hardness, thickness, disintegration time and in-vitro drug release studies were performed. Formulation M3 containing 10% w/w of dehydrated banana powder has shown disintegration time of 20 sec and 97% of drug release within 25 minutes. The formulation M6 containing 10% w/w of cross povidone has shown disintegration time of 18 sec and 94% of drug release within 20 minutes.
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